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Target enzymes involved in central metabolism (e.g., glycolysis, TCA cycle, lipid metabolism).

Agonists or antagonists for G protein–coupled receptors, one of the largest drug target classes.

Modulators of the Leukemia Inhibitory Factor and STAT3 signaling axis.

Inhibitors or openers that modulate ion channels or transporters.

Regulators of the nuclear factor kappa-light-chain-enhancer of activated B cells, key in inflammation and immunity.

Modulators of the mitogen-activated protein kinase cascade involved in proliferation and differentiation.

Compounds targeting cyclins, CDKs, or checkpoints to control cell division.

Inhibitors/activators of histone modifiers or DNA methylation enzymes.

Modified E3 ligase ligands used in PROTACs or molecular glues.

Target ion channels, neurotransmitter receptors, or synaptic proteins.